Humanized Mice: Human Immune System NOG and hGMCSF/hIL3 NOG Mice

Humanized mouse models, generated by transplanting pre-validated CD34+ human stem cells into NOG and hGMCSF/ hIL3 NOG mouse, are extremely useful in basic and applied human disease research. HuMurine Technologies is a CRO (contract research organization) that provides specialized research services based on the Human Immune System NOG and hGMCSF/hIL3 NOG mouse (Hu-M™ Mouse). The Hu-M™ Mouse is stably engrafted with a functional human immune system and is ideal for doing efficacy and safety assessment of therapeutics that requires a human immune response.

The Hu-M™ Mice are generated by a proprietary two-step validation process using pre-validated CD34+ human stem cells and 8 color flow cytometry.

HuMurine currently offers contract research services on cancer biology (immunotherapy), infectious diseases (vaccines or antiviral therapies), inflammation (cytokine release syndrome, immunity assessment), assessment of immune response against human restricted diseases (human antibody or T cell response), and gene therapies. We also offer specialized contract services so please contact us to discuss your need.

The Hu-M platform has wide ranging applications for efficacy and safety studies for :

  • Immune checkpoint inhibitors
  • Human hematopoiesis
  • Vaccines
  • Infectious diseases (HIV, TB)
  • Gene therapies
  • Graft vs. host disease
  • Cytokine release syndrome
 

The Hu-M Development Process: Generation of the Hu-M Mice

Hu-M CIEA NOG Mouse® in 1214 weeks

humurine-process

 

Salient Features of The Hu-M Mouse

  • image3Reconstituted with pre-qualified hematopoietic CD34+ stem cells resulting in superior and consistent chimerization
  • 8-color flow cytometric validation for human lymphocytes in the peripheral blood 10-15 weeks post engraftment.
  • Customizable flow cytometric matrix for up to 8 flurochromes.
  • Interactive and responsive scientific team provides exceptional guidance in study design and execution
  • Special pricing available for pilot and proof-of-concept study schemes

Latest News

  • HuMurine Announces Licensing Agreement for hGMCSF/hIL3-NOG (HuNOG-EXL) mice from Taconic Biosciences

    January 22, 2016

    HuMurine Announces Licensing Agreement for hGMCSF/hIL3-NOG (HuNOG-EXL) mice from Taconic Biosciences

    HuMurine Technologies (HuMurine) has announced today that it has entered into an exclusive licensing agreement with Taconic Biosciences (Taconic) for the commercial use of the hGM-CSF/hIL3-NOG mouse. The hGM-CSF/hIL3-NOG mouse expresses human GM-CSF and IL-3 cytokines in the NOG mouse background, supporting higher overall engraftment levels of human hematopoietic stem cells and enhanced levels of myeloid cell differentiation, in comparison to the conventional NOG mouse.